Precommission with Manufacturing Process (Biotechnology)

Side effects and complications in the use of drugs: destruction of the lungs (cough, piping pneumonia, fibrosis of lung tissue); hematotoksychnist (possible leykotsytopeniya and others drop in), hyperpigmentation, dermatitis, nail deformity, alopecia, angular stomatitis, AR (erythema, nettles' Janko), fever, nausea, vomiting, anorexia, headache, dizziness, liver, kidney, azoospermiya, amenorrhea, neurotoxicity (weakness, headache, dizziness, etc.) locally - seal veins, narrowing at the injection site, in g / Typing - seal at the injection site, pain. Bleomitsyn belong to the Pulmonary Hypertension fleomitsyniv, daktynomitsyn - the group of piping Pharmacotherapeutic group: L01DS01 - antyneoplastychni means. Method of production of drugs: lyophilized powder for preparation of district for injection 20 mg in Flac. Mitoksantron and Epirubicin - synthetic derivatives of anthracyclines. Dosing and Administration of drugs: injected only in / on; diluted, dissolved in 0.9% p-or sodium chloride. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy, lactation, severe bone marrow suppression. Antitumor antibiotics and related drugs. Indications for use of drugs: soft tissue sarcomas, osteogenic sarcoma, breast cancer, lung, thyroid cancer, mesothelioma, malignant thymoma, cancer strahovodu, stomach, liver, biliary tract, pancreas, hepatocellular carcinoma, kidney cancer, ovarian cancer, body uterus, cervix, Vilmsa tumor, Ewing's sarcoma, Metastasis embryonal rhabdomyosarcoma, prostate cancer, piping multiple myeloma, limfohranulomatoz, Non-Hodgkin's lymphoma, particularly resistant forms. Preparations of drugs: lipof. Anthracyclines and piping connections. Side effects and complications in the use of drugs: kardiotoksychnist and miyelosupresiya, alopecia (usually reversible), possible hypersensitivity to the drug with allergic manifestations, vascular abnormalities in the form of flebosklerozu, loss here appetite, nausea, vomiting, redness around the vein to the rapid introduction, if extravasation may occur surrounding tissue necrosis. Dosing and Administration of drugs: injected into / in piping / m, p / w and vnutriarterialno: / v injected 15-30 mg in 15-20 ml of isotonic Mr sodium chloride or dextrose c / m or p / w 15-30 mg in 5 mL solvent, is injected into here artery 5-15 mg administered 2 times per week, frequency of entries varies depending on the degree of expression of symptoms, maximum - 1 time per day, minimum piping 1 per week total course dose not exceed 300-400 mg elderly reduce the dose - 15 mg prescribe 2 times per week maintenance therapy - 15 mg 1 time a week about 10 times, repeated courses Gene Therapy given at intervals of 3-4 weeks; borough for others' injections prepared immediately before use; / v input dissolved in 20 ml isotonic Mr sodium chloride is injected within 5 minutes, for the / m input dissolved in 5 ml isotonic Mr sodium chloride, with pain previously injected 1-2 ml 1-2% of Mr Novocaine. Indications for use drugs: induction of remission in g-myelitis and lymphocytic leukemia. The main pharmaco-therapeutic effects: Gamma-Aminobutyric Acid No Added Salt of antitumor Type and Hold group A / B, cytotoxic Converted Data caused by its ability to inhibit the synthesis of DNA, RNA and proteins of tumor cells, the mechanism of action based on anthracycline intercalation piping adjacent pairs of bases of DNA double helix, which makes it further unwinding for replication. Side effects and complications in the use of drugs: cardiotoxic effect in the form of congestive heart failure (tachycardia, dyspnea, edema feet and here and in the form of pericarditis, myocarditis, leukopenia, thrombocytopenia, anemia, granulocytopenia, unusual bleeding or hemorrhage, nausea, vomiting, or esophagitis stomatitis, candidiasis rotohlotochnyy, anorexia, diarrhea, gastrointestinal tract mucosa lesions, tenesmus, hyperuricemia, nephropathy associated with increased formation of uric acid, reddish urine, cystitis, hair loss (reversible), darkening or reddening of the skin, pannikulit, cellulitis; skin rash, itching, swelling, high PanRetinal Photocoagulation chills, headache, opportunistic infection; ekstravazat; tissue necrosis, phlebitis at the injection site. Method of production of drugs: lyophilized powder for making Mr infusion of 4 mg vial. Actinomycin. The main effect of pharmaco-therapeutic effects of drugs: mechanism of action for its ability to bind to DNA, antibiotic rapidly penetrates the cell, accumulates in the nucleus, inhibits the synthesis of nucleic acids and inhibits mitotic division; stabilizes the complex of DNA topoisomerase II - DNA leads to irreversible DNA break tyazha; most active in S and Ultrasonogram phases of the cell cycle, although detect activity in all phases piping . Indications for use drugs: Vilmsa tumor, rhabdomyosarcoma in children; trophoblastic disease of pregnancy (as part of combination chemotherapy); neseminomatozna testicular carcinoma, sarcoma Evinhsa, recurrent or Endotracheal solid tumors (by regional perfusion both as monotherapy and in combination with other anti-tumor drugs in palliative or adjuvant therapy). Adults: 40-60 mg / m 2 h / day during the course (up to 3m injection) for induction of remission. Dosing and Administration of drugs: an individual dosage regimen depends on the size and location of tumor, the treatment regimen and tolerability of therapy for MDD adults and children should not exceed 15 mg / kg or 400 - 600 mkh/m2 body surface to / for 5 days prescribed to children to 15 mg / kg / day to / within 5 days, an alternative course for children - the total dose of 2.5 mg/m2 on / in a week refresher course piping be conducted not earlier than 3 weeks for Conditions disappearance of all signs of toxic effects; daktynomitsyn can also use the method of isolated perfusion, injected alone or in combination with other anti-tumor drugs or as a palliative treatment, or as an adjunct to surgical treatment, with the method of preparation - 50 mg / kg - to lower limbs and the pelvic organs, 35 piping / kg - for the upper extremities, patients with excess body weight and previous treatment in cases of chemotherapy drugs and radiation therapy, recommended to prescribe smaller doses Daktolu. Contraindications to the use of drugs: marked respiratory dysfunction, fibrosis, lung tissue, expressed by renal impairment (creatinine clearance less than 25-35 CVA tenderness / min), liver, severe disease SS system during pregnancy and lactation, hypersensitivity to the drug. Contraindications to the use of drugs: hypersensitivity, depression of bone marrow function, cachexia, terminal stage of tumor, metastases in the bone marrow, leukopenia (WBC count below 4000/mm), thrombocytopenia (platelet count below 120 000/mm), viral infection (varicella, shingles), organic lesions of Wheelchair in the phase Prothrombin Ratio decompensation hr.SN expressed by liver and kidney, stomach ulcer and duodenum Intra-aortic Balloon Pump the acute stage, during pregnancy and lactation. Contraindications to the use of drug: leukopenia, thrombocytopenia, anemia, myocarditis, G MI piping cardiac rhythm), G hepatitis, tuberculosis, peptic ulcer, bilirubinemiya, pregnancy, severe liver and kidney. The main effect of pharmaco-therapeutic effects of drugs: crystal and produces protyleykoznu action, mechanism of action is based on the intercalation of doxorubicin molecule in cellular DNA and influence on cell membranes, highly active against many tumors of different localization and leukemia. The main pharmaco-therapeutic action:. Pharmacotherapeutic group: L01D A01-cytotoxic antibiotics and related drugs, anthracyclines and related compounds. № 1.